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apalutamide will lessen the level or impact of modafinil by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Prevent or Use Alternate Drug. Coadministration of apalutamide, a solid CYP3A4 inducer, with drugs which have been CYP3A4 substrates can result in reduced exposure to these remedies.Whilst not Primarily typical, some Health professio